A systematic review comparing the efficacy of Propofol vs midazolam on the incidence of PONV in the adult population. The review suggests the use of either medication alone or in combination with other anti-emetics to effectively prevent and/or reduce the incidence or severity of PONV. Both medications have anti-emetics properties and CRNAs should implement either medication into their practice to prophylactically treat PONV. More research on this topic is needed because there was limited research pertaining to midazolam as an anti-emetic.