Achieving effective hemostasis following femoral artery access for angiogram procedures is essential for minimizing complications and promoting patient recovery. Traditionally, manual compression has been used; however, vascular closure devices (VCDs) have gained prominence for their potential to reduce recovery time and improve patient comfort. This evidence-based project compares VCDs and manual compression to determine their relative effectiveness in decreasing post-procedural complications such as hematomas, bleeding, and infection. The project integrates Faye Abdellah’s Patient-Centered Nursing Theory to guide individualized care decisions, emphasizing patient-specific factors like vessel anatomy and comorbidities. A post-procedural care algorithm was developed for advanced practice registered nurses (APRNs) and registered nurses (RNs) to standardize recovery care, enhance staff confidence, and reduce variability. Implementation included staff training, retrospective chart review, and pre- and post-surveys to measure nursing comfort, adherence, and patient outcomes. Findings are expected to show improvements in patient satisfaction, reduced complications, faster ambulation, and enhanced workflow efficiency. This project highlights the importance of individualized, evidence-based interventions and standardized protocols to optimize patient care and operational outcomes in vascular recovery settings. Broader implications include guiding clinical decision-making, supporting nursing education, and contributing to policy development for post-angiogram care.